This course provides a comprehensive introduction to the engineering principles, design, operation, and safety of nuclear power plants. It covers the fundamental concepts of nuclear physics and reactor theory, including neutron interactions, fission processes, and chain reactions, which form the basis of energy generation in nuclear systems. Students will study the main components and systems of nuclear power plants, such as reactors, fuel assemblies, control rods, coolant systems, steam generators, and containment structures. The course examines different types of nuclear reactors, including pressurized water reactors (PWR), boiling water reactors (BWR), and advanced reactor designs. Key topics include thermal-hydraulics, heat transfer, radiation shielding, reactor kinetics, and fuel cycle analysis. Emphasis is placed on safety analysis, risk assessment, and regulatory frameworks governing nuclear power plants, along with accident analysis and mitigation strategies. The course also explores operational aspects such as plant control, instrumentation, maintenance, and performance optimization. Environmental impacts, radioactive waste management, and the role of nuclear energy in sustainable power generation are discussed. By the end of the course, students will have a solid understanding of nuclear power plant systems and will be able to analyze and evaluate their performance, safety, and efficiency from an engineering perspective.